Paper review: protein-interaction mapping in search of effective drug targets

Paper review: Protein-interaction mapping in search of effective drug targets
Amitabha Chaudhuri, John Chant
BioEssays 2005

This review discusses modular organization of protein interaction network, improving and accessing quality of interaction data and impact on medicine.
Protein interaction is viewed as three level of organization: 1) signaling complex (~ an interaction?) 2) signaling module (assembly of signaling complex having defined input and measurable output) 3) signaling network (assembly of signaling module and possesses emergent properties).  
Verities of methods to assess the quality of protein interaction are reviewed.
Finally, challenges in discovering targets by protein-interaction mapping are discuss. Any interesting methodology or approach for drug target identification is discussed as paper title suggested.
It concludes successful application of protein-interaction mapping in target discovery requires integration of verity of biological information. (Oblivious  enough?) But not how?


Reviewer: Kyaw Tun